| Rank | Title | Weekend |
|---|---|---|
| 1 | Who Framed Roger Rabbit / 1988 | £1,506,863 |
| 2↓ (1) | Scrooged / 1988 | £614,458 |
| 3 | The Bedroom Window / 1988 | £189,606 |
| 4↓ (3) | Cocoon: The Return / 1988 | £88,324 |
| 5↓ (2) | Tucker: The Man and His Dream / 1988 | £85,288 |
| 6↓ (4) | A Fish Called Wanda / 1988 | £74,045 |
| 7↓ (5) | Colors / 1988 | £61,825 |
| 8↓ (6) | The Hidden / 1988 | £39,992 |
| 9↓ (7) | Big / 1988 | £32,238 |
| 10↓ (8) | Buster / 1988 | £15,937 |
| 11↔ (11) | Midnight Run / 1988 | £9,784 |
| 12↓ (9) | Stormy Monday / 1988 | £9,149 |
| 13↓ (12) | Good Morning Vietnam / 1988 | £4,438 |
| 14↓ (10) | Patty Hearst / 1988 | £4,303 |
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