| Rank | Title | Weekend |
|---|---|---|
| 1 | Charlie's Angels / 2000 | £3,182,114 |
| 2↓ (1) | What Lies Beneath / 2000 | £540,882 |
| 3↑ (5) | Billy Elliot / 2000 | £356,434 |
| 4↓ (2) | Bedazzled / 2000 | £355,866 |
| 5↓ (3) | Little Nicky / 2000 | £273,249 |
| 6↓ (4) | Pitch Black / 2000 | £269,474 |
| 7↓ (6) | Dinosaur / 2000 | £261,935 |
| 8↔ (8) | The Little Vampire / 2000 | £209,667 |
| 9↓ (7) | The Kid / 2000 | £190,259 |
| 10↔ (10) | Coyote Ugly / 2000 | £186,499 |
| 11 | The Skulls / 2000 | £149,297 |
| 12↓ (9) | Road Trip / 2000 | £101,749 |
| 13↑ (15) | Memento / 2000 | £80,866 |
| 14↓ (11) | The Way of the Gun / 2000 | £63,772 |
| 15↓ (12) | Wonder Boys / 2000 | £57,022 |
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