| Rank | Title | Weekend |
|---|---|---|
| 1 | Meet the Parents / 2000 | £2,261,785 |
| 2↓ (1) | How the Grinch Stole Christmas / 2000 | £1,614,860 |
| 3↔ (3) | 102 Dalmatians / 2000 | £956,729 |
| 4↓ (2) | Charlie's Angels / 2000 | £647,461 |
| 5 | The 6th Day / 2000 | £586,401 |
| 6↓ (4) | What Lies Beneath / 2000 | £124,051 |
| 7↑ (8) | Billy Elliot / 2000 | £51,171 |
| 8↑ (9) | Small Time Crooks / 2000 | £48,928 |
| 9↑ (10) | Coyote Ugly / 2000 | £42,910 |
| 10↓ (6) | The Art of War / 2000 | £41,195 |
| 11↓ (7) | Urban Legends: Final Cut / 2000 | £39,056 |
| 12↑ (13) | Memento / 2000 | £25,658 |
| 13↓ (5) | Red Planet / 2000 | £21,699 |
| 14↓ (11) | Bedazzled / 2000 | £15,005 |
| 15 ⇅ (re) | Mohabbatein / 2000 | £14,964 |
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