| Rank | Title | Weekend |
|---|---|---|
| 1 | American Pie 2 / 2001 | £5,508,709 |
| 2↓ (1) | Moulin Rouge / 2001 | £864,326 |
| 3↔ (3) | Enigma / 2001 | £529,725 |
| 4↓ (2) | A.I.: Artificial Intelligence / 2001 | £515,756 |
| 5↔ (5) | Amélie / 2001 | £478,466 |
| 6↓ (4) | Mike Bassett: England Manager / 2001 | £402,227 |
| 7↓ (6) | The Score / 2001 | £335,830 |
| 8↓ (7) | The Fast and the Furious / 2001 | £271,083 |
| 9↓ (8) | A Knights Tale / 2001 | £166,848 |
| 10↓ (9) | Cats & Dogs / 2001 | £146,299 |
| 11 | The Pledge / 2001 | £142,100 |
| 12↔ (12) | Shrek / 2001 | £83,745 |
| 13 | Atlantis: The Lost Empire / 2001 | £79,695 |
| 14↔ (14) | Dr. Dolittle 2 / 2001 | £62,438 |
| 15↓ (11) | Scary Movie 2 / 2001 | £54,030 |
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