| Rank | Title | Weekend |
|---|---|---|
| 1 | Mr. & Mrs. Smith / 2005 | £3,943,422 |
| 2↓ (1) | Star Wars Episode III: Revenge of the Sith / 2005 | £1,598,734 |
| 3↓ (2) | Sin City / 2005 | £1,027,813 |
| 4↓ (3) | The Pacifier / 2005 | £384,705 |
| 5↑ (6) | House of Wax / 2005 | £253,036 |
| 6↓ (5) | Monster-in-Law / 2005 | £240,094 |
| 7↓ (4) | The League of Gentlemens Apocalypse / 2005 | £234,491 |
| 8↓ (7) | Millions / 1991 | £119,592 |
| 9 | A Married Woman / 2005 | £115,286 |
| 10↓ (8) | Kingdom of Heaven / 2005 | £62,205 |
| 11↔ (11) | Bunty Aur Babli / 2005 | £49,241 |
| 12↓ (9) | The Hitchhikers Guide to the Galaxy / 2005 | £47,554 |
| 13↔ (13) | The Consequences of Love / 2005 | £29,317 |
| 14↓ (12) | Valiant / 2005 | £26,339 |
| 15↓ (10) | It's All Gone Pete Tong / 2005 | £21,224 |
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