| Rank | Title | Weekend |
|---|---|---|
| 1 | X-Men: The Last Stand / 2006 | £7,091,820 |
| 2↓ (1) | The Da Vinci Code / 2006 | £4,920,995 |
| 3 | The Wild / 2006 | £1,033,153 |
| 4↓ (2) | Mission:Impossible III / 2006 | £756,785 |
| 5 | Curious George / 2006 | £330,232 |
| 6 | Fanaa / 2006 | £300,563 |
| 7↓ (3) | Prime / 2006 | £265,674 |
| 8↓ (4) | Ice Age: The Meltdown / 2006 | £130,112 |
| 9 | Friends With Money / 2006 | £95,092 |
| 10↓ (5) | Waiting... / 2006 | £80,611 |
| 11↓ (6) | When a Stranger Calls / 2006 | £70,802 |
| 12↓ (8) | Brick / 2006 | £70,483 |
| 13 | Down In the Valley / 2005 | £39,803 |
| 14↓ (7) | Confetti / 2006 | £38,964 |
| 15 | The Thief Lord / 2006 | £38,737 |
| 16 ⇅ (re) | Deep Sea 3D / 2006 | £16,340 |
| 17↓ (16) | Fateless / 2005 | £6,007 |
| 18↓ (17) | Romance and Cigarettes / 2005 | £2,310 |
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