| Rank | Title | Weekend |
|---|---|---|
| 1 | Cars / 2006 | £2,668,968 |
| 2↓ (1) | Pirates of the Caribbean: Dead Man's Chest / 2006 | £2,625,103 |
| 3↓ (2) | The Break Up / 2006 | £1,414,268 |
| 4↓ (3) | Superman Returns / 2006 | £1,345,200 |
| 5↓ (4) | Stormbreaker / 2006 | £780,255 |
| 6↓ (5) | Garfield 2 / 2006 | £562,057 |
| 7↓ (6) | Over the Hedge / 2006 | £361,910 |
| 8 | Stay Alive / 2006 | £140,126 |
| 9↓ (7) | The Wind That Shakes the Barley / 2006 | £131,351 |
| 10 | Omkara / 2006 | £91,294 |
| 11 | Angel A / 2005 | £47,825 |
| 12 | Warrior King / 2005 | £34,295 |
| 13↓ (8) | Little Fish / 2005 | £28,640 |
| 14↔ (14) | Thank You For Smoking / 2006 | £17,844 |
| 15↔ (15) | Deep Sea 3D / 2006 | £17,197 |
| 16 | Renaissance / 2006 | £14,623 |
| 17↓ (16) | Pretty Persuasion / 2005 | £1,350 |
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