| Rank | Title | Weekend |
|---|---|---|
| 1↑ (2) | Cars / 2006 | £1,340,219 |
| 2↑ (3) | Pirates of the Caribbean: Dead Man's Chest / 2006 | £1,320,059 |
| 3↓ (1) | Miami Vice / 2006 | £1,186,987 |
| 4 | Monster House / 2006 | £1,030,305 |
| 5 | Nacho Libre / 2006 | £993,948 |
| 6 | Kabhi Alvida Naa Kehna / 2006 | £749,243 |
| 7↓ (4) | The Break Up / 2006 | £554,633 |
| 8↓ (5) | My Super Ex-Girlfriend / 2006 | £486,043 |
| 9 | Lady In the Water / 2006 | £452,744 |
| 10↓ (6) | Superman Returns / 2006 | £407,580 |
| 11↓ (9) | Garfield 2 / 2006 | £316,712 |
| 12↓ (7) | Stormbreaker / 2006 | £278,545 |
| 13↓ (8) | The Ant Bully / 2006 | £209,393 |
| 14↓ (10) | Over the Hedge / 2006 | £153,142 |
| 15↓ (11) | The Wind That Shakes the Barley / 2006 | £89,761 |
| 16↑ (19) | Warrior King / 2005 | £29,153 |
| 17↓ (16) | Little Fish / 2005 | £24,485 |
| 18 | Tideland / 2006 | £24,469 |
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