| Rank | Title | Weekend |
|---|---|---|
| 1 | You, Me and Dupree / 2006 | £1,636,249 |
| 2↓ (1) | Snakes On a Plane / 2006 | £698,166 |
| 3↔ (3) | Pirates of the Caribbean: Dead Man's Chest / 2006 | £631,287 |
| 4↓ (2) | Cars / 2006 | £556,581 |
| 5↓ (4) | Monster House / 2006 | £527,181 |
| 6↓ (5) | John Tucker Must Die / 2006 | £509,219 |
| 7 | Severance / 2006 | £483,152 |
| 8 | Volver / 2006 | £433,283 |
| 9↓ (7) | Miami Vice / 2006 | £325,431 |
| 10↓ (6) | Nacho Libre / 2006 | £306,134 |
| 11↓ (9) | Garfield 2 / 2006 | £242,748 |
| 12↓ (8) | Kabhi Alvida Naa Kehna / 2006 | £159,392 |
| 13↓ (10) | The Break Up / 2006 | £140,569 |
| 14↓ (12) | A Scanner Darkly / 2006 | £129,632 |
| 15↓ (13) | Superman Returns / 2006 | £126,064 |
| 16↔ (16) | Deep Sea 3D / 2006 | £18,045 |
| 17↔ (17) | Thank You For Smoking / 2006 | £7,880 |
| 18↑ (19) | Renaissance / 2006 | £2,090 |
| 19↓ (18) | Little Fish / 2005 | £1,642 |
| 20 ⇅ (re) | Tideland / 2006 | £1,424 |
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