| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | You, Me and Dupree / 2006 | £746,602 |
| 2↔ (2) | Little Man / 2006 | £671,248 |
| 3 | Right At Your Door / 2006 | £441,548 |
| 4↔ (4) | The Sentinel / 2006 | £392,053 |
| 5 | Little Miss Sunshine / 2006 | £349,810 |
| 6↓ (3) | The Wicker Man / 2006 | £291,332 |
| 7↑ (8) | Crank / 2006 | £260,167 |
| 8↑ (9) | Volver / 2006 | £240,074 |
| 9↓ (6) | Pirates of the Caribbean: Dead Man's Chest / 2006 | £226,233 |
| 10 | Pulse / 2006 | £210,409 |
| 11 | Beerfest / 2006 | £208,782 |
| 12↓ (7) | Monster House / 2006 | £197,031 |
| 13↓ (5) | Cars / 2006 | £180,397 |
| 14↓ (12) | John Tucker Must Die / 2006 | £157,823 |
| 15↔ (15) | Lage Raho Munna Bhai / 2006 | £151,570 |
| 16 | Snow Cake / 2006 | £72,657 |
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