| Rank | Title | Weekend |
|---|---|---|
| 1↑ (2) | Avatar / 2009 | £2,817,009 |
| 2↑ (4) | The Princess and the Frog / 2010 | £1,725,519 |
| 3 | The Lovely Bones / 2009 | £1,637,579 |
| 4↓ (1) | Valentine's Day / 2010 | £1,583,142 |
| 5↔ (5) | Percy Jackson and the Olympians: The Lightning Thief / 2010 | £1,487,446 |
| 6↓ (3) | The Wolfman / 2010 | £774,890 |
| 7 | Solomon Kane / 2009 | £611,886 |
| 8↑ (9) | Alvin and the Chipmunks: The Squeakquel / 2009 | £608,154 |
| 9↓ (7) | Invictus / 2009 | £570,801 |
| 10↔ (10) | Astro Boy / 2009 | £523,215 |
| 11↓ (6) | My Name Is Khan / 2010 | £448,747 |
| 12↓ (8) | A Single Man / 2010 | £377,751 |
| 13↓ (11) | Sherlock Holmes / 2009 | £214,110 |
| 14↓ (12) | Youth In Revolt / 2010 | £154,021 |
| 15 | The Last Station / 2010 | £135,368 |
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