| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | The Secret Life of Pets / 2016 | £3,624,751 |
| 2 | The Legend of Tarzan / 2016 | £3,570,350 |
| 3 | Now You See Me 2 / 2016 | £2,964,641 |
| 4↓ (2) | Absolutely Fabulous: The Movie / 2016 | £2,316,349 |
| 5↓ (3) | Central Intelligence / 2016 | £1,342,004 |
| 6 | Sultan / 2016 | £1,048,417 |
| 7↓ (4) | Independence Day: Resurgence / 2016 | £782,975 |
| 8↓ (5) | The Conjuring 2: The Enfield Case / 2016 | £401,155 |
| 9 | The Neon Demon / 2016 | £126,996 |
| 10↓ (6) | Me Before You / 2016 | £126,907 |
| 11 | Maggies Plan / 2016 | £102,534 |
| 12↓ (8) | The Jungle Book / 2016 | £70,891 |
| 13↓ (11) | Zootopia / 2016 | £65,064 |
| 14↓ (7) | The Nice Guys / 2016 | £49,553 |
| 15↓ (9) | Alice Through the Looking Glass / 2016 | £37,526 |
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