| Rank | Title | Weekend |
|---|---|---|
| 1 | The 40 Year Old Virgin / 2005 | £1,757,540 |
| 2 | Red Eye / 2005 | £891,582 |
| 3↓ (2) | Charlie and the Chocolate Factory / 2005 | £660,671 |
| 4↓ (1) | The Dukes of Hazzard / 2005 | £618,448 |
| 5 | The Business / 2005 | £531,267 |
| 6↓ (4) | Crash / 2004 | £414,383 |
| 7↓ (3) | Bewitched / 2005 | £345,473 |
| 8↓ (6) | Herbie Fully Loaded / 2005 | £315,084 |
| 9↓ (8) | The Adventures of Sharkboy and Lavagirl 3D / 2005 | £289,666 |
| 10↓ (5) | The Cave / 2005 | £258,668 |
| 11↓ (7) | The Island / 2005 | £161,468 |
| 12↓ (9) | Madagascar / 2005 | £120,772 |
| 13↓ (11) | Wedding Crashers / 2005 | £73,920 |
| 14↔ (14) | No Entry / 2005 | £71,393 |
| 15↓ (10) | Unleashed / 2005 | £63,584 |
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