| Rank | Title | Weekend |
|---|---|---|
| 1 | Ice Age: The Meltdown / 2006 | £9,775,974 |
| 2 | She's the Man / 2006 | £994,304 |
| 3 | Alien Autopsy / 2006 | £796,119 |
| 4↓ (1) | Inside Man / 2006 | £791,970 |
| 5↓ (2) | Failure to Launch / 2006 | £462,094 |
| 6↓ (4) | Hostel / 2006 | £392,782 |
| 7↓ (3) | The Shaggy Dog / 2006 | £278,466 |
| 8 | The Dark / 1993 | £265,084 |
| 9↓ (5) | The Pink Panther / 2006 | £253,913 |
| 10↓ (6) | Basic Instinct 2 / 2006 | £218,670 |
| 11↓ (7) | Firewall / 2006 | £218,378 |
| 12↓ (9) | Yours, Mine & Ours / 2006 | £173,255 |
| 13↓ (8) | The Ringer / 2006 | £133,696 |
| 14↓ (10) | V For Vendetta / 2006 | £100,821 |
| 15↓ (11) | The White Countess / 2005 | £83,280 |
| 16 | The Squid and the Whale / 2005 | £71,203 |
| 17↔ (17) | Romance and Cigarettes / 2005 | £17,060 |
| 18 | Deep Sea 3D / 2006 | £16,219 |
| 19 ⇅ (re) | Memoirs of a Geisha / 2005 | £10,483 |
| 20↓ (18) | The Ballad of Jack and Rose / 2005 | £8,729 |
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