| Rank | Title | Weekend |
|---|---|---|
| 1 | Pirates of the Caribbean: Dead Man's Chest / 2006 | £13,740,784 |
| 2↓ (1) | Over the Hedge / 2006 | £2,167,916 |
| 3↓ (2) | Just My Luck / 2006 | £424,436 |
| 4↓ (3) | The Fast and the Furious: Tokyo Drift / 2006 | £332,089 |
| 5↔ (5) | The Wind That Shakes the Barley / 2006 | £269,144 |
| 6↓ (4) | The Lake House / 2006 | £247,884 |
| 7↓ (6) | The Da Vinci Code / 2006 | £121,850 |
| 8 | District B13 / 2006 | £98,747 |
| 9↓ (7) | X-Men: The Last Stand / 2006 | £87,582 |
| 10↑ (12) | Krrish / 2006 | £60,344 |
| 11↓ (8) | Fearless / 2006 | £54,492 |
| 12↑ (13) | Thank You For Smoking / 2006 | £48,135 |
| 13↓ (9) | Hard Candy / 2006 | £36,008 |
| 14 | Heading South / 2006 | £35,787 |
| 15↓ (11) | Reeker / 2006 | £33,030 |
| 16 ⇅ (re) | Deep Sea 3D / 2006 | £14,031 |
| 17 ⇅ (re) | Pretty Persuasion / 2005 | £4,635 |
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