| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Pirates of the Caribbean: Dead Man's Chest / 2006 | £6,048,087 |
| 2 | Superman Returns / 2006 | £4,337,637 |
| 3↓ (2) | Over the Hedge / 2006 | £915,510 |
| 4↑ (5) | The Wind That Shakes the Barley / 2006 | £167,518 |
| 5↓ (3) | Just My Luck / 2006 | £160,471 |
| 6↓ (4) | The Fast and the Furious: Tokyo Drift / 2006 | £93,661 |
| 7↓ (6) | The Lake House / 2006 | £77,018 |
| 8 | Golmaal: Fun Unlimited / 2006 | £51,267 |
| 9↓ (7) | The Da Vinci Code / 2006 | £50,745 |
| 10↓ (8) | District B13 / 2006 | £34,302 |
| 11↑ (12) | Thank You For Smoking / 2006 | £28,990 |
| 12↓ (10) | Krrish / 2006 | £27,852 |
| 13 | Elementarteilchen / 2006 | £25,823 |
| 14↓ (9) | X-Men: The Last Stand / 2006 | £22,288 |
| 15↓ (14) | Heading South / 2006 | £20,911 |
| 16↔ (16) | Deep Sea 3D / 2006 | £13,791 |
| 17↔ (17) | Pretty Persuasion / 2005 | £1,708 |
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