| Rank | Title | Weekend |
|---|---|---|
| 1↑ (2) | The Departed / 2006 | £1,957,646 |
| 2↓ (1) | The Devil Wears Prada / 2006 | £1,870,080 |
| 3 | Open Season / 2006 | £1,666,750 |
| 4↓ (3) | Click / 2006 | £917,814 |
| 5 | The History Boys / 2006 | £794,672 |
| 6 | The Texas Chainsaw Massacre: The Beginning / 2006 | £669,760 |
| 7↓ (4) | Hoodwinked / 2006 | £513,245 |
| 8↓ (5) | World Trade Center / 2006 | £431,227 |
| 9↓ (6) | The Queen / 2006 | £269,178 |
| 10↓ (7) | Children of Men / 2006 | £213,944 |
| 11 | Stick It / 2006 | £131,043 |
| 12↓ (8) | Accepted / 2006 | £120,979 |
| 13↓ (9) | Little Miss Sunshine / 2006 | £93,075 |
| 14 | Driving Lessons / 2006 | £84,070 |
| 15↓ (14) | Volver / 2006 | £29,735 |
| 16↓ (11) | Little Man / 2006 | £28,328 |
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