| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | The Departed / 2006 | £1,456,564 |
| 2↔ (2) | The Devil Wears Prada / 2006 | £1,358,015 |
| 3 | Barnyard / 2006 | £1,022,890 |
| 4↓ (3) | Open Season / 2006 | £1,014,844 |
| 5 | The Guardian / 2006 | £826,569 |
| 6 | The Grudge 2 / 2006 | £773,422 |
| 7↓ (5) | The History Boys / 2006 | £639,051 |
| 8↓ (4) | Click / 2006 | £609,588 |
| 9 | The Last Kiss / 2006 | £431,071 |
| 10↓ (7) | Hoodwinked / 2006 | £354,214 |
| 11 | Don / 2006 | £295,982 |
| 12 | Marie Antoinette / 2006 | £283,883 |
| 13↓ (6) | The Texas Chainsaw Massacre: The Beginning / 2006 | £272,009 |
| 14↓ (8) | World Trade Center / 2006 | £182,470 |
| 15↓ (9) | The Queen / 2006 | £162,001 |
| 16↓ (14) | Driving Lessons / 2006 | £60,050 |
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