| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan / 2006 | £4,510,657 |
| 2 | The Prestige / 2006 | £1,184,996 |
| 3↓ (2) | Saw III / 2006 | £895,594 |
| 4↓ (3) | Step Up / 2006 | £634,316 |
| 5↓ (4) | The Departed / 2006 | £447,635 |
| 6↔ (6) | Open Season / 2006 | £389,945 |
| 7 | Breaking and Entering / 2006 | £364,886 |
| 8↓ (7) | Barnyard / 2006 | £355,048 |
| 9↓ (5) | The Devil Wears Prada / 2006 | £347,306 |
| 10↓ (8) | Sixty Six / 2006 | £219,257 |
| 11 | Starter For 10 / 2006 | £207,345 |
| 12↓ (11) | Click / 2006 | £132,983 |
| 13↔ (13) | Hoodwinked / 2006 | £121,638 |
| 14↓ (9) | The History Boys / 2006 | £113,166 |
| 15↓ (12) | Umrao Jaan / 2006 | £86,723 |
| 16↑ (17) | Driving Lessons / 2006 | £10,360 |
| 17↓ (16) | Scenes of a Sexual Nature / 2006 | £10,138 |
| 18↑ (19) | The Asphalt Jungle / 1950 Re-Release | £3,896 |