| Rank | Title | Weekend |
|---|---|---|
| 1 | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan / 2006 | £6,242,344 |
| 2↓ (1) | Saw III / 2006 | £1,403,657 |
| 3↓ (2) | Step Up / 2006 | £696,369 |
| 4↓ (3) | The Departed / 2006 | £556,823 |
| 5↔ (5) | The Devil Wears Prada / 2006 | £460,062 |
| 6↓ (4) | Open Season / 2006 | £402,941 |
| 7↓ (6) | Barnyard / 2006 | £355,612 |
| 8 | Sixty Six / 2006 | £292,295 |
| 9↓ (8) | The History Boys / 2006 | £176,329 |
| 10 | Little Children / 2006 | £158,012 |
| 11↓ (7) | Click / 2006 | £154,039 |
| 12 | Umrao Jaan / 2006 | £136,011 |
| 13↓ (10) | Hoodwinked / 2006 | £124,795 |
| 14↓ (13) | Don / 2006 | £123,773 |
| 15↓ (9) | A Good Year / 2006 | £122,753 |
| 16 | Scenes of a Sexual Nature / 2006 | £55,617 |
| 17↓ (16) | Driving Lessons / 2006 | £23,829 |
| 18 ⇅ (re) | Deep Sea 3D / 2006 | £9,071 |
| 19 | The Asphalt Jungle / 1950 Re-Release | £7,430 |
| 20 | Waist Deep / 2006 | £6,561 |