| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Casino Royale / 2006 | £8,546,238 |
| 2↔ (2) | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan / 2006 | £1,470,923 |
| 3 | The Santa Clause 3: The Escape Clause / 2006 | £1,274,774 |
| 4 | Tenacious D In the Pick of Destiny / 2006 | £922,574 |
| 5 | Jackass Number Two / 2006 | £735,274 |
| 6 | Dhoom 2 / 2006 | £415,701 |
| 7↓ (3) | The Prestige / 2006 | £327,984 |
| 8 | Pans Labyrinth / 2006 | £298,432 |
| 9↓ (4) | Step Up / 2006 | £166,146 |
| 10↓ (5) | Saw III / 2006 | £109,339 |
| 11↓ (6) | Barnyard / 2006 | £84,089 |
| 12 | Hollywoodland / 2006 | £65,735 |
| 13↓ (7) | Open Season / 2006 | £56,287 |
| 14↓ (8) | The Departed / 2006 | £50,300 |
| 15↓ (11) | Starter For 10 / 2006 | £40,311 |
| 16 ⇅ (re) | Deep Sea 3D / 2006 | £7,700 |
| 17 | Something New / 2006 | £6,664 |
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