| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Casino Royale / 2006 | £5,307,969 |
| 2 | Flushed Away / 2006 | £3,106,874 |
| 3↔ (3) | The Santa Clause 3: The Escape Clause / 2006 | £1,001,546 |
| 4↓ (2) | Borat: Cultural Learnings of America For Make Benefit Glorious Nation of Kazakhstan / 2006 | £776,812 |
| 5 | Deck the Halls / 2006 | £600,047 |
| 6↓ (4) | Tenacious D In the Pick of Destiny / 2006 | £385,350 |
| 7 | Stranger Than Fiction / 2006 | £368,627 |
| 8↓ (5) | Jackass Number Two / 2006 | £318,985 |
| 9↓ (8) | Pans Labyrinth / 2006 | £246,342 |
| 10↓ (6) | Dhoom 2 / 2006 | £235,956 |
| 11↓ (7) | The Prestige / 2006 | £139,777 |
| 12 | Big Nothing / 2006 | £83,829 |
| 13 | The Nightmare Before Christmas / 1993 Re-Release | £65,668 |
| 14 ⇅ (re) | Breaking and Entering / 2006 | £48,516 |
| 15↓ (9) | Step Up / 2006 | £39,295 |
| 16 | London to Brighton / 2006 | £38,493 |
| 17↔ (17) | Something New / 2006 | £548 |
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