| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Toy Story 3 / 2010 | £3,162,944 |
| 2↑ (3) | Inception / 2010 | £1,681,130 |
| 3 | The Last Airbender / 2010 | £1,653,776 |
| 4↓ (2) | Knight and Day / 2010 | £1,529,478 |
| 5 | The Sorcerers Apprentice / 2010 | £1,140,532 |
| 6↓ (4) | Step Up 3D / 2010 | £1,078,100 |
| 7↓ (6) | The Karate Kid / 2010 | £764,748 |
| 8↓ (7) | The A-Team / 2010 | £762,570 |
| 9↓ (5) | Cats & Dogs: The Revenge of Kitty Galore / 2010 | £488,905 |
| 10 | Tinker Bell and the Great Fairy Rescue / 2010 | £288,544 |
| 11↓ (8) | Shrek Forever After / 2010 | £246,835 |
| 12↓ (9) | The Twilight Saga: Eclipse / 2010 | £148,549 |
| 13 | The Secret In Their Eyes / 2010 | £85,467 |
| 14↓ (11) | Coco Chanel and Igor Stravinsky / 2010 | £43,426 |
| 15↓ (10) | Gainsbourg / 2010 | £41,128 |
| 16 | Le Refuge / 2010 | £13,808 |
| 17↓ (16) | Nanny Mcphee and the Big Bang / 2010 | £9,009 |
| 18 | Black Dynamite / 2010 | £6,400 |
| 19↓ (18) | London River / 2010 | £4,097 |
| 20↑ (23) | The Ghost / 2010 | £854 |
| 21↓ (19) | Down Terrace / 2010 | £783 |
| 22 | The Final / 2010 | £228 |
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