| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Toy Story 3 / 2010 | £4,666,021 |
| 2 | Knight and Day / 2010 | £2,404,163 |
| 3↑ (4) | Inception / 2010 | £2,259,595 |
| 4 | Step Up 3D / 2010 | £2,015,403 |
| 5 | Cats & Dogs: The Revenge of Kitty Galore / 2010 | £1,553,005 |
| 6↓ (2) | The Karate Kid / 2010 | £1,411,486 |
| 7↓ (3) | The A-Team / 2010 | £1,386,868 |
| 8↓ (5) | Shrek Forever After / 2010 | £362,464 |
| 9↓ (6) | The Twilight Saga: Eclipse / 2010 | £324,469 |
| 10↓ (8) | Gainsbourg / 2010 | £87,125 |
| 11 | Coco Chanel and Igor Stravinsky / 2010 | £52,874 |
| 12 | Aisha / 2010 | £52,759 |
| 13↑ (14) | Tooth Fairy / 2010 | £32,216 |
| 14↓ (7) | The Rebound / 2010 | £28,913 |
| 15↓ (9) | Predators / 2010 | £23,129 |
| 16↑ (17) | Nanny Mcphee and the Big Bang / 2010 | £10,603 |
| 17 | Undertow / 2010 | £9,896 |
| 18↑ (22) | London River / 2010 | £3,373 |
| 19↑ (24) | Down Terrace / 2010 | £2,125 |
| 20↑ (21) | Four Lions / 2010 | £1,759 |
| 21 | Eccentricities of a Blonde Haired Girl / 2010 | £1,645 |
| 22↓ (20) | Robin Hood / 2010 | £1,453 |
| 23↔ (23) | The Ghost / 2010 | £1,373 |
| 24 | Mummy and Me / 2010 | £830 |
| 25↓ (19) | StreetDance 3D / 2010 | £532 |
| 26↑ (28) | 4.3.2.1 / 2010 | £235 |
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