| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Harry Potter and the Deathly Hallows Part 1 / 2010 | £8,344,776 |
| 2 | Unstoppable / 2010 | £1,714,871 |
| 3 | London Boulevard / 2010 | £577,224 |
| 4↓ (2) | Due Date / 2010 | £560,179 |
| 5 | The American / 2010 | £411,707 |
| 6↓ (3) | Despicable Me / 2010 | £241,944 |
| 7 | The Girl Who Kicked the Hornets Nest / 2010 | £219,259 |
| 8↓ (5) | Jackass 3D / 2010 | £119,369 |
| 9↓ (4) | Skyline / 2010 | £92,931 |
| 10 | Machete / 2010 | £90,423 |
| 11 | Break Ke Baad / 2010 | £85,708 |
| 12↓ (10) | Another Year / 2010 | £59,505 |
| 13↓ (7) | Alpha and Omega / 2010 | £58,293 |
| 14↓ (9) | The Social Network / 2010 | £50,943 |
| 15↓ (8) | Guzaarish / 2010 | £48,952 |
| 16↑ (17) | Made In Dagenham / 2010 | £8,860 |
| 17 ⇅ (re) | Burke and Hare / 2010 | £6,521 |
| 18 | Nandalala / 2010 | £3,137 |
| 19 | Leap Year / 2010 | £2,424 |
| 20 | An Ordinary Execution / 2010 | £2,326 |
| 21 | Sleeping Princess / 2010 | £1,692 |
| 22↓ (18) | Africa United / 2010 | £1,491 |
| 23 ⇅ (re) | The Illusionist / 2010 | £1,296 |
| 24 | Waiting For "Superman" / 2010 | £1,022 |
| 25 | Allah Ke Banday / 2010 | £682 |
| 26↓ (22) | Mr. Nice / 2010 | £254 |
| 27↓ (26) | Over Your Cities Grass Will Grow / 2010 | £58 |
| 28↓ (21) | The Arbor / 2010 | £24 |
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