| Rank | Title | Weekend |
|---|---|---|
| 1 | Gullivers Travels / 2010 | £7,028,747 |
| 2↓ (1) | Little Fockers / 2010 | £2,614,802 |
| 3 | Love and Other Drugs / 2010 | £1,606,253 |
| 4 | The Way Back / 2010 | £1,327,650 |
| 5↓ (3) | TRON Legacy / 2010 | £1,259,569 |
| 6↓ (2) | The Chronicles of Narnia: The Voyage of the Dawn Treader / 2010 | £1,207,264 |
| 7↓ (4) | Harry Potter and the Deathly Hallows Part 1 / 2010 | £1,040,826 |
| 8↓ (6) | Megamind / 2010 | £612,327 |
| 9↓ (7) | The Tourist / 2010 | £396,758 |
| 10↓ (8) | Animals United / 2010 | £243,442 |
| 11↓ (10) | Burlesque / 2010 | £183,023 |
| 12↓ (9) | Arthur and the Great Adventure / 2010 | £130,582 |
| 13↓ (5) | Tees Maar Khan / 2010 | £98,033 |
| 14↓ (12) | Fred: The Movie / 2010 | £85,877 |
| 15↔ (15) | Unstoppable / 2010 | £31,407 |
| 16↑ (18) | Chatroom / 2010 | £15,629 |
| 17↔ (17) | Monsters / 2010 | £12,415 |
| 18↑ (19) | Another Year / 2010 | £11,587 |
| 19↑ (20) | London Boulevard / 2010 | £4,359 |
| 20↑ (21) | Made In Dagenham / 2010 | £1,537 |
| 21↑ (22) | Burke and Hare / 2010 | £708 |
| 22↑ (28) | All Good Children / 2010 | £371 |
| 23↔ (23) | Cuckoo / 2009 | £133 |
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