| Rank | Title | Weekend |
|---|---|---|
| 1 | Space Jam: A New Legacy / 2021 | £31,650,000 |
| 2↓ (1) | Black Widow / 2021 | £26,251,000 |
| 3 | Escape Room: Tournament of Champions / 2021 | £8,800,000 |
| 4↓ (2) | Fast and Furious 9 / 2021 | £7,620,000 |
| 5↓ (3) | The Boss Baby 2: Family Business / 2021 | £4,720,000 |
| 6↓ (4) | The Forever Purge / 2021 | £4,160,000 |
| 7↓ (5) | A Quiet Place: Part II / 2021 | £2,300,000 |
| 8 | Roadrunner: A Film About Anthony Bourdain / | £1,900,000 |
| 9↓ (6) | Cruella / 2021 | £1,112,000 |
| 10 | Pig / 2021 | £945,000 |
| 11↓ (7) | The Hitman's Wife's Bodyguard / 2021 | £775,000 |
| 12↓ (10) | Zola / 2020 | £744,075 |
| 13↓ (8) | Peter Rabbit 2: The Runaway / 2021 | £605,000 |
| 14↓ (9) | In the Heights / 2021 | £365,000 |
| 15↓ (11) | The Conjuring: The Devil Made Me Do It / 2021 | £330,000 |
| 16↓ (12) | Summer of Soul (...Or, When the Revolution Could Not Be Televised) / 2021 | £182,000 |
| 17↓ (13) | 12 Mighty Orphans / 2021 | £94,800 |
| 18↓ (14) | Spirit Untamed / 2021 | £55,000 |
| 19↓ (15) | Queen Bees / 2021 | £49,000 |
| 20↓ (16) | I Carry You With Me / | £26,752 |
| 21↓ (17) | Raya and the Last Dragon / 2021 | £18,000 |
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