| Directed by | |
|---|---|
 | Roger Spottiswoode |
| Starring | ||
|---|---|---|
 | Matthew Modine | Dr. Don Francis |
| Alan Alda | Dr. Robert Gallo |
| Patrick Bauchau | Dr. Luc Montagnier |
| Nathalie Baye | Dr. Francoise Barre |
| Christian Clemenson | Dr. Dale Lawrence |
| David Clennon | Mr. Johnstone |
| Phil Collins | Eddie Papasano |
| Bud Cort | Antique shop owner |
| Alex Courtney | Dr. Mika Popovic |
| David Dukes | Dr. Mervyn Silverman |
 | Richard Gere | The Choreographer |
| David Marshall Grant | Dennis Seeley |
| Ronald Guttman | Dr. Jean-Claude Chermann |
| Glenne Headly | Dr. Mary Guinan |
| Anjelica Huston | Dr. Betsy Reisz |
| Ken Jenkins | Dr. Dennis Donohue |
| Richard Jenkins | Dr. Marc Conant |
| Tcheky Karyo | Dr. Willy Rozenbaum |
| Swoosie Kurtz | Mrs. Johnstone |
| Jack Laufer | Brian McDonough |
| Donal Logue | Bobbi Campbell |
 | Steve Martin | The Brother |
| Richard Masur | William W. Darrow, PhD |
| Dakin Matthews | Congressman Phil Burton |
 | Ian McKellen | Bill Kraus |
| Peter McRobbie | Dr. Max Essex |
| Lawrence Monoson | Chip |
| Jeffrey Nordling | Gaetan Dugas |
| Saul Rubinek | Dr. Jim Curran |
| Charles Martin Smith | Dr. Harold Jaffe |
| Stephen Spinella | Brandy Alexander |
| Lily Tomlin | Dr. Selma Dritz |
| BD Wong | Kico Govantes |
| Walter Addison | Blood Bank executive |
| Jill Andre | Red Cross spokesperson |
| Alan Barry | Hemophiliac patient |
| Neal Benari | Dr. Tom Spira |
| David Dean Bottrell | Man #3 |
| Rico Bueno | Bellevue Hospital Patient |
| Bill Carmichael | Delivery Man |
| Christopher Carroll | Dr. Aaron Kellner |
| Reg E. Cathey | Staff Doctor #2 |
| John Del Regno | Man in Grand Central |
| John Durbin | 6th Man |
| Mogens Eckert | Chief Executive (Copenhagen) |
| Carey Eidel | Tennis Player |
| Robert Briscoe Evans | 2nd Reporter |
| Richard Fancy | Dr. Michael Gottlieb |
| Keythe Farley | Lab Technician |
| Christopher John Fields | Lawyer |
| Dave Florek | Doughnut Shop Counterman |
| Niki Guluchi | Sudanese Girl |
| Yasmine Golchan | Dr. Francoise Brun-Vezinet |
| Patrick Gorman | Charles Dauget |
| James Greene | Dr. Alvin Freedman-Kien |
| Jeff Hayenga | Dr. Bruce Voeller |
| Daniel Henning | Blaine |
| Ike Ikediashi | Sudanese Boy |
| Laura Innes | Hemophiliac Representative |
| Laura James | Margaret Heckler |
| Michael Kearns | Cleve |
| Erasor Kemie | Sudanese Student |
| Jack Kenny | San Francisco Activist |
| Thomas Kopache | Blood Bank Executive |
| Clyde Kusatsu | Blood Bank Executive |
| Frank LiBay | Desk Clerk |
| Rob LaBelle | Gay Rights Activist |
| Neal Lerner | 1st Man |
| Rene Le Vant | Blood Bank Executive |
| Geoff Lower | Dr. David Simpson |
| Anthony Lucero | Mailroom Man |
| James Mastrantonio | 8th Man |
| Jon Shear | Greg |
| Rosemary Murphy | Blood Bank Executive |
| Susanne Olsen | Intern (Copenhagen) |
| Angela Paton | Woman in Denver |
| Sierra Pecheur | Female Reporter |
| Miguel Perez | Reporter |
| Martin Raymond | 4th Man |
| Jeremy Regan | Ticket Seller |
| Robert Martin Robinson | Chief Administrator (French) |
| Valeri Ross | Jim's Secretary |
| Hildur Ruriks | Female Danish 2nd Executive |
| Tom Schanley | Waiter |
| Sean Whitesell | Country Club Attendant |
| Michael Winters | Middle-aged Man |
| William Wintersole | Dr. Paul Florino |
| Lenny Wolpe | Dr. Joseph Bove |
| Peter Allen | Self |
| Edafe Okurume | Sudanese Driver |
| Arthur Ashe | Self (epilogue sequence) |
| Tina Chow | Self (epilogue sequence) |
| Aric Cushing | Street Walker |
| Brad Davis | Billy Hayes (epilogue sequence) |
| Denholm Elliott | Mr. Emerson (epilogue sequence) |
| Ryal Haakenson | Physician / Conference's Audience Member |
| Rock Hudson | Self (epilogue sequence) |
 | Michael Jackson | Self (epilogue sequence) |
| Magic Johnson | Self (epilogue sequence) |
| Trey King | AIDS Patient |
| Giorgio Kokosin | Hospital patient |
| Liberace | Self (Epilogue) |
| John Lizzi | Congressional Aide |
| Geoffrey Lower | Dr. David Simpson |
| Roger Gail Lyon | Self |
| Richard Marcus | Reporter |
| Freddie Mercury | Self (epilogue sequence) |
| Paul Moncrief | Court Photographer |
| Roger Mudd | Self |
| Anthony Perkins | Self (epilogue sequence) |
| Princess Diana | Self - in epilogue sequence |
| Ronald Reagan | Self |
| Max Robinson | Self (epilogue sequence) |
| Richie Solomon | Procession Marcher |
| Michael Szymanski | Reporter |
| Elizabeth Taylor | Self (epilogue sequence) |
| Tom Waddell | Self |
| Ryan White | Self (epilogue sequence) |
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USA release date: 11th September 1993
Japan release date: 21st December 1993
Spain release date: 21st January 1994
Germany release date: 3rd February 1994
Uruguay release date: 25th February 1994
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