| Directed by | |
|---|---|
 | Judd Apatow |
| Starring | ||
|---|---|---|
 | Seth Rogen | Ben Stone |
 | Katherine Heigl | Alison Scott |
 | Paul Rudd | Pete |
 | Leslie Mann | Debbie |
| Jason Segel | Jason |
| Jay Baruchel | Jay |
| Jonah Hill | Jonah |
| Martin Starr | Martin |
| Lo Mutuc | Jodi |
| Iris Apatow | Charlotte |
| Maude Apatow | Sadie |
| Joanna Kerns | Alison's Mom |
 | Harold Ramis | Ben's Dad |
 | Alan Tudyk | Jack |
 | Kristen Wiig | Jill |
 | Bill Hader | Brent |
 | Ken Jeong | Dr. Kuni |
| Craig Robinson | Club Doorman |
| Tim Bagley | Dr. Pellagrino |
| Loudon Wainwright III | Dr. Howard |
| Stephanie Mnookin | Dr. Howard's Nurse |
| Adam Scott | Samuel |
| J.P. Manoux | Dr. Angelo |
| Mo Collins | Female Doctor |
| B.J. Novak | Young Doctor |
| Tami Sagher | Wardrobe Lady |
| Brianna Brown | Alison's Friend |
| Catherine Reitman | Alison's Friend |
| Nick Thune | Alison's Friend |
 | Paul Feig | Fantasy Baseball Guy |
| Ben Meyerson | Fantasy Baseball Guy |
| Wayne Federman | Fantasy Baseball Guy |
| Melinda Bennett | Dr. Pellagrino's Nurse |
| Matthew McKane | Club Bartender |
| Steven Brill | Ben's Boss |
| Ana Mercedes | Maria |
| Nadine Griffith | Maternity Nurse at Desk |
| Diane Schaller | Delivery Nurse |
| Emersen Riley | Jonah's Girlfriend |
| Stormy Daniels | Lap Dancer |
| Nautica Thorn | Lap Dancer |
| Mary Brill | Real Estate Agent |
| Lolita Mastrolia | Daughter in Waiting Room |
| Joseph T. Mastrolia | Father in Waiting Room |
| Tracy Hartley | Lamaze Instructor |
| Jeffrey L. Wilson | Record Store Customer |
 | Jessica Alba | Self (uncredited) |
 | Steve Carell | Self (uncredited) |
| Andy Dick | Self (uncredited) |
| James Franco | Sol (uncredited) |
| Eva Mendes | Self (uncredited) |
| Ryan Seacrest | Self (uncredited) |
| Dax Shepard | Self (uncredited) |
| Michelle Woods | Waitress (uncredited) |
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