| Directed by | ||
|---|---|---|
 | Bobby Farrelly | |
 | Peter Farrelly | |
| Starring | ||
|---|---|---|
 | Chris Rock | Osmosis Jones |
 | Laurence Fishburne | Thrax |
 | David Hyde Pierce | Drix |
| Brandy Norwood | Leah |
| William Shatner | Mayor Phlegmming |
 | Ron Howard | Tom Colonic |
| Kid Rock | Kidney Rock |
| Kenny Olson | Kidney Rock |
| Jason Krause | Kidney Rock |
| Joe C. | Kidney Rock |
| Stefanie Eulinberg | Kidney Rock |
| Jimmie Bones | Kidney Rock |
| Uncle Kracker | Kidney Rock |
| Jonathan Adams | Additional Character Voice |
| Carlos Alazraqui | Additional Character Voice |
| Keith Anthony | Additional Character Voice |
| Eddie Barth | Additional Character Voice |
| Sally Ann Brooks | Additional Character Voice |
| Rodger Bumpass | Additional Character Voice |
| Michael Carven | Additional Character Voice |
| Paul Christie | Additional Character Voice |
| Janis Dardaris | Additional Character Voice |
| Wendy Dillon | Additional Character Voice |
| Antonio Fargas | Additional Character Voice |
| Eddie Frierson | Additional Character Voice |
| Donald Fullilove | Additional Character Voice |
| Jackie Gonneau | Additional Character Voice |
| Shannon Gregory | Additional Character Voice |
| Rif Hutton | Additional Character Voice |
| Richard Steven Horvitz | Additional Character Voice |
| Art Kimbro | Additional Character Voice |
| Joyce Kurtz | Additional Character Voice |
| Anne Lockhart | Additional Character Voice |
| Sherry Lynn | Additional Character Voice |
| Danny Mann | Additional Character Voice |
| Mickie McGowan | Additional Character Voice |
| John Melendez | Additional Character Voice |
| Hector Mercado | Additional Character Voice |
| Paul Pape | Additional Character Voice |
| Marilyn Pasekoff | Additional Character Voice |
| Chris Phillips | Additional Character Voice |
| Lynne Redding | Additional Character Voice |
| Al Rodrigo | Additional Character Voice |
| Herschel Sparber | Additional Character Voice |
| Doug Stone | Additional Character Voice |
| Steve Susskind | Additional Character Voice |
| Keri Tombazian | Additional Character Voice |
| Paul Tuerpe | Additional Character Voice |
| Robert Wisdom | Additional Character Voice |
 | Bill Murray | Frank Detorre |
| Molly Shannon | Mrs. Boyd |
| Chris Elliott | Bob |
| Elena Franklin | Shane Detorre |
| Danny Murphy | Zookeeper Superintendent |
| Jack McCullough | Zookeeper |
| Kathy Wege | Mrs. Claris, Volcano Lady |
| Will Dunn | Oyster Boy |
| Jackie Flynn | School Janitor |
| Kelsey Jordan | Bus Girl #1 |
| A.B. Farrelly | Bus Girl #2 |
| Jesse Peter | Laughing Boy |
| John-Eliot Jordan | Pea Soup Manager |
| Nancy Byers | Pea Soup Supervisor |
| Kevin J. Flynn | Docky's Clamshack Waiter |
| Sean Gildea | Dreamy Photographer |
| Kathryn Frick | Nurse #1 |
| Nikki Tyler-Flynn | Nurse #2 |
| Elizabeth Jordan | Nurse #3 |
| Zen Gesner | Emergency Room Doctor #1 |
| Marc Hyman | Emergency Room Doctor #2 |
| Zak Penn | Emergency Room Doctor #3 |
| Bob O'Brien | The Zoo Visitors & Staff |
| Tom Beachene | The Zoo Visitors & Staff |
| Diane Conrad | The Zoo Visitors & Staff |
| Judy Conrad | The Zoo Visitors & Staff |
| Bob Fennessy | The Zoo Visitors & Staff |
| John Britten | The Zoo Visitors & Staff |
| Katie Britten | The Zoo Visitors & Staff |
| Marlene Malone | The Zoo Visitors & Staff |
| Grady O'Connor | The Zoo Visitors & Staff |
| Barbara O'Connor | The Zoo Visitors & Staff |
| Jacqueline Wentzell | The Zoo Visitors & Staff |
| Morgan Wentzell | The Zoo Visitors & Staff |
| Jamie Heres | The Zoo Visitors & Staff |
| Jimmy Heres | The Zoo Visitors & Staff |
| Thomas Jordan | The Zoo Visitors & Staff |
| Ruth Meyer | The Zoo Visitors & Staff |
| Mandy Marsh | The Zoo Visitors & Staff |
| Tommy Barbieri | The Zoo Visitors & Staff |
| Allison Barbieri | The Zoo Visitors & Staff |
| Erica Johnson | The Zoo Visitors & Staff |
| Sydney J. Bartholomew Jr. | The Zoo Visitors & Staff |
| Bill Beauchene | The Science Fair Contestants & Families |
| Buzz Dunn | The Science Fair Contestants & Families |
| Laura Dunn | The Science Fair Contestants & Families |
| Krista-Jean Forand | The Science Fair Contestants & Families |
| Kena Flynn | The Science Fair Contestants & Families |
| Christina Kacmar | The Science Fair Contestants & Families |
| Diana O'Donnell | The Science Fair Contestants & Families |
| Dick Silva | The Science Fair Contestants & Families |
| Allison Kacmar | The Science Fair Contestants & Families |
| Nicole Brathwaite | The Volcano Gal |
| Emily ODay | The Volcano Gal |
| Brianna Cabral | The Volcano Gal |
| Catherine Dunphy | The Volcano Gal |
| Chandler Vuilleumier | The Volcano Gal |
| Bill Wade | Pea Soup Staff |
| Bo Cleary | Pea Soup Staff |
| Bruce McIntyre | Pea Soup Staff |
| Colleen O'Donnell | Docky's Clamshack |
| Maryjane Foy | Docky's Clamshack |
| Jo Ann Nicewicz | Docky's Clamshack |
| Jillian Nicewicz | Docky's Clamshack |
| Docky | The Bikini Gang |
| Heidi Hetzel | The Bikini Gang |
| Patricia Guiggey | The Bikini Gang |
| Rachael Kasner | The Bikini Gang |
| George Kouri | The Bikini Gang |
| Joe Murphy | The Bikini Gang |
| Dick Rubin | The Bikini Gang |
| Amy Suhay | The Bikini Gang |
| Brian Mone | Police Officer |
| Sean Fitzgerald | Police Officer |
| Beth Jordan | The Emergency Room Nurse |
| Mattie Ostiguy | The Emergency Room Nurse |
| Grace Costa | The Emergency Room Nurse |
| Maura O'Brien | The Emergency Room Nurse |
| Lori Alan | Germs |
| Steve Alterman | Billy |
| Jack Angel | Various |
| Michael Bell | Germs |
| Bob Bergen | Various |
| Susan Blu | Various |
| John J. Burke | Student |
| Cathy Cavadini | Various |
| Robert Clotworthy | Various |
| Jennifer Darling | Various |
| Debi Derryberry | Various |
| Paul Eiding | Various |
| Jonathan Evans-Jones | Violinist Cell |
| Bill Farmer | Various |
| Kathy Farrelly | Nurse |
| Shawn Fogarty | Father at Science Fair |
| Teresa Ganzel | Various |
| Jess Harnell | Various |
| Bridget Hoffman | Various |
| Mona Marshall | Various |
| Camden Munson | |
| David Ossman | Scabies |
| Patrick Pinney | Various |
| Phil Proctor | Various |
| Jan Rabson | Various |
| Peter Renaday | Various |
| Neil Ross | Germs |
| Joel Silver | Police Chief |
| Ben Stein | Doc |
| James Arnold Taylor | Coffee Holding White Blood Cell |
| Marcelo Tubert | Collin |
| Ben Urann | Student |
| Jillian Wheeler | Student |
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Cameroon release date: 10th August 2001
Mexico release date: 10th August 2001 USA release date: 10th August 2001
Chile release date: 13th September 2001
Brazil release date: 14th September 2001 Brazil
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