| Directed by | ||
|---|---|---|
 | George C. Wolfe | |
| Starring | ||
|---|---|---|
 | Renée Elise Goldsberry | Henrietta Lacks |
| Sylvia Grace Crim | Mary Kubick |
| Reed Birney | Dr. George Gey |
| Karen Wheeling Reynolds | Mrs. Margaret Gey |
| John C. Vennema | Board Administrator |
| Chasiti Ferrell | Baby Deborah |
| Chelsea Ferrell | Baby Deborah |
 | Rose Byrne | Rebecca Skloot |
| Ruben Santiago-Hudson | Dr. Roland Pattillo |
| Oprah Winfrey | Deborah Lacks |
| Jaedon Godley | Davon |
| Rocky Carroll | Sonny Lacks |
| John Douglas Thompson | Lawrence Lacks |
| Roger Robinson | Day Lacks |
| Adriane Lenox | Barbara Lacks |
| Kyanna Simone | Teenage Deborah |
| Jane Rumbaua | Dr. Susan Hsu |
| Byron Jennings | Dr. Victor McKusick |
| Jaylon Gordon | Alfred |
| Reg E. Cathey | Zakariyya |
| Leslie Uggams | Sadie |
| Leon Lamar | Cootie |
| John Beasley | Cliff |
| Andrea Frye | Gladys |
| Jazzy Ellis | Young Gladys |
| Tinashe Kajese | Young Sadie |
| Patrick R. Walker | Cousin Fred |
| L. Warren Young | Young Day Lacks |
| John Benjamin Hickey | Bill Watson |
 | Ellen Barkin | Sasha Walz |
| Courtney B. Vance | Sir Lord Keenan Kester Cofield |
| Michael Gaston | Richard Wilson |
| Kate Bond | Young Woman |
| Peter Gerety | Paul Lurz |
| Tyvonna Jones | Teenage Elsie |
| Bill Martin Williams | Crownsville Administrator |
| Mary Shaw | Woman Pumping Gas |
| Alfred Carter Jr. | Turner Station Man |
| Dhemi Mathis | Toddler Deborah |
| Damohr Mathis | Toddler Deborah |
| Tian Richards | Young Lawrence |
| Kermit Burns III | Young Cootie |
| Lisa Arrindell | Ethel |
| Linden Harris | Galen |
| Jordan Eli Arellano | Young Sonny |
| DeMarco Arrington | Young Zakariyya |
| Aniyla Johnson | Young Deborah |
| Gabriel Ebert | Christoph Lengauer |
| John Jacob Anderson | Scientist |
| Matthew Bernard | John Hopkins Student |
| Kathi Binkley | Archive Receptionist |
| Raphael Dante Carr Jr. | Young Sonny |
| John Chancellor | Newscaster |
| Ninja N. Devoe | Country Girl Mae |
| Clint Edwards | Scientist |
| Kayla Ellenwood | John Hopkins Student |
| Sean Freeland | Charlie |
| Elizabeth Hackler | Rebecca's Co-Worker |
| Christine Hameed | Friend of Family |
| Debbie Hartner | Nurse |
| Monica Haynes | Doctor |
| Adrienne Johnson | Church Member |
| Todd Lee | Doctor |
| Miguel Angel Marrero | Scientist |
| Sage Mayer | Young Boy |
| Jock McKissic | Carl the Mechanic |
| Neal McNeil | Lacks Neighbor |
| John Merical | Senior Scientist |
| Tatom Pender | John Hopkins Nurse |
| Earl Poitier | Cousin Josh |
| Candy Rachor | Scientist |
| Patti Schellhaas | Pedestrian |
| David Shae | Reporter |
| Tashaun Stanfill-Perry | Henrietta Lacks Neighbor |
| Laura Alain Steele | Female Boss |
| Corey Jason Thomas | Church Parishoner |
| Alpha Trivette | First Administrator |
| Christopher Van Escobar | Chris the Intern |
| Kent Wagner | Scientist |
| Terrence V. Walker | Church Patron |
| William Walker | Hospital Utility Worker |
| Dolan Wilson | Counter Man |
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