| Rank | Title | Weekend |
|---|---|---|
| 1 | Saw III / 2006 | £2,522,521 |
| 2 | Step Up / 2006 | £1,212,725 |
| 3↓ (1) | The Departed / 2006 | £1,036,275 |
| 4↔ (4) | Open Season / 2006 | £970,353 |
| 5↓ (2) | The Devil Wears Prada / 2006 | £900,618 |
| 6↓ (3) | Barnyard / 2006 | £743,162 |
| 7↑ (8) | Click / 2006 | £425,093 |
| 8↓ (7) | The History Boys / 2006 | £419,878 |
| 9 | A Good Year / 2006 | £376,962 |
| 10↔ (10) | Hoodwinked / 2006 | £357,921 |
| 11↓ (6) | The Grudge 2 / 2006 | £347,927 |
| 12↓ (5) | The Guardian / 2006 | £336,379 |
| 13↓ (11) | Don / 2006 | £291,137 |
| 14↓ (9) | The Last Kiss / 2006 | £223,243 |
| 15↓ (12) | Marie Antoinette / 2006 | £133,590 |
| 16↔ (16) | Driving Lessons / 2006 | £33,361 |
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