| Rank | Title | Weekend |
|---|---|---|
| 1 | Get Him to the Greek / 2010 | £1,569,556 |
| 2↓ (1) | Killers / 2010 | £389,509 |
| 3↓ (2) | Sex and the City 2 / 2010 | £357,066 |
| 4↔ (4) | Prince of Persia: The Sands of Time / 2010 | £159,684 |
| 5↓ (3) | StreetDance 3D / 2010 | £159,260 |
| 6↔ (6) | Death At a Funeral / 2010 | £118,648 |
| 7 | The Collector / 2010 | £109,519 |
| 8↓ (5) | Letters to Juliet / 2010 | £104,134 |
| 9↔ (9) | Robin Hood / 2010 | £89,457 |
| 10↓ (7) | Wild Target / 2010 | £88,287 |
| 11↓ (8) | Tooth Fairy / 2010 | £78,171 |
| 12↓ (10) | Brooklyn's Finest / 2010 | £76,274 |
| 13 | Whatever Works / 2010 | £72,678 |
| 14 | When In Rome / 2010 | £61,512 |
| 15↓ (11) | Raavan / 2010 | £27,230 |
| 16↑ (18) | Four Lions / 2010 | £17,829 |
| 17 | Tetro / 2010 | £11,770 |
| 18↑ (20) | The Killer Inside Me / 2010 | £10,442 |
| 19↓ (17) | 4.3.2.1 / 2010 | £10,242 |
| 20 | Good Hair / 2010 | £5,644 |
| 21↑ (22) | Black Death / 2010 | £3,056 |
| 22↑ (27) | Nanny Mcphee and the Big Bang / 2010 | £2,239 |
| 23 | Villa Amalia / 2010 | £2,152 |
| 24↑ (29) | American: The Bill Hicks Story / 2010 | £575 |
| 25↑ (28) | The Ghost / 2010 | £246 |
| 26↑ (33) | The Infidel / 2010 | £94 |
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