| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Toy Story 3 / 2010 | £8,115,193 |
| 2 | The Karate Kid / 2010 | £4,882,306 |
| 3 | The A-Team / 2010 | £3,569,505 |
| 4↓ (2) | Inception / 2010 | £3,229,651 |
| 5↓ (4) | Shrek Forever After / 2010 | £899,851 |
| 6↓ (3) | The Twilight Saga: Eclipse / 2010 | £779,142 |
| 7↓ (5) | The Rebound / 2010 | £178,972 |
| 8 | Gainsbourg / 2010 | £135,031 |
| 9↓ (6) | Predators / 2010 | £112,088 |
| 10 | Once Upon a Time In Mumbaai / 2010 | £54,780 |
| 11↓ (7) | Khatta Meetha / 2010 | £46,851 |
| 12↓ (8) | Get Him to the Greek / 2010 | £44,001 |
| 13↓ (9) | Splice / 2010 | £34,478 |
| 14 ⇅ (re) | Tooth Fairy / 2010 | £27,576 |
| 15↓ (11) | Heartbreaker / 2010 | £21,519 |
| 16 | South of the Border / 2010 | £20,591 |
| 17↔ (17) | Nanny Mcphee and the Big Bang / 2010 | £10,227 |
| 18 | Beautiful Kate / 2010 | £6,538 |
| 19↑ (22) | StreetDance 3D / 2010 | £3,568 |
| 20↑ (23) | Robin Hood / 2010 | £3,177 |
| 21↔ (21) | Four Lions / 2010 | £2,822 |
| 22↓ (20) | London River / 2010 | £2,501 |
| 23↑ (26) | The Ghost / 2010 | £2,204 |
| 24 | Down Terrace / 2010 | £1,919 |
| 25↔ (25) | Went the Day Well? / 1942 Re-Release | £1,150 |
| 26↑ (27) | Wild Target / 2010 | £855 |
| 27 | Separado / 2010 | £540 |
| 28↔ (28) | 4.3.2.1 / 2010 | £23 |
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