| Rank | Title | Weekend |
|---|---|---|
| 1 | The Last Exorcism / 2010 | £1,104,856 |
| 2 | Dinner For Schmucks / 2010 | £940,586 |
| 3↔ (3) | Toy Story 3 / 2010 | £934,423 |
| 4↓ (1) | Grown Ups / 2010 | £878,141 |
| 5↓ (2) | Scott Pilgrim Vs. the World / 2010 | £702,542 |
| 6 | The Switch / 2010 | £666,018 |
| 7↓ (4) | The Expendables / 2010 | £627,776 |
| 8↓ (5) | Salt / 2010 | £509,319 |
| 9↓ (6) | Piranha 3D / 2010 | £446,895 |
| 10↓ (7) | Inception / 2010 | £417,302 |
| 11↓ (10) | Marmaduke / 2010 | £364,098 |
| 12↓ (8) | Diary of a Wimpy Kid / 2010 | £307,031 |
| 13↓ (9) | Avatar / 2009 | £274,145 |
| 14↓ (12) | The Girl Who Played With Fire / 2010 | £216,472 |
| 15 | We Are Family / 2010 | £162,863 |
| 16 | Certified Copy / 2010 | £76,703 |
| 17↓ (16) | The Illusionist / 2010 | £66,160 |
| 18 | Why Did I Get Married Too? / 2010 | £41,459 |
| 19 | Jonah Hex / 2010 | £36,456 |
| 20 | Bonded By Blood / 2010 | £25,890 |
| 21↔ (21) | Nanny Mcphee and the Big Bang / 2010 | £11,273 |
| 22 | Soul Boy / 2010 | £9,027 |
| 23 | 22 Bullets / 2010 | £4,528 |
| 24 | Chhevan Dariya / 2010 | £2,103 |
| 25 | Cherry Tree Lane / 2010 | £1,287 |
| 26 | No Impact Man / 2010 | £1,006 |
| 27 | Splintered / 2010 | £996 |
| 28↓ (22) | London River / 2010 | £953 |
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