| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | The Other Guys / 2010 | £1,292,144 |
| 2 | Eat Pray Love / 2010 | £1,165,234 |
| 3 | The Town / 2010 | £1,005,039 |
| 4 | The Hole / 2010 | £906,722 |
| 5↓ (2) | Devil / 2010 | £528,908 |
| 6↓ (4) | Toy Story 3 / 2010 | £472,449 |
| 7↓ (5) | Grown Ups / 2010 | £384,119 |
| 8↓ (3) | Resident Evil: Afterlife / 2010 | £367,675 |
| 9↓ (6) | Tamara Drewe / 2010 | £245,643 |
| 10↓ (8) | Marmaduke / 2010 | £244,285 |
| 11↓ (10) | Diary of a Wimpy Kid / 2010 | £205,241 |
| 12↑ (13) | Inception / 2010 | £174,186 |
| 13↓ (7) | The Last Exorcism / 2010 | £162,133 |
| 14↓ (11) | Scott Pilgrim Vs. the World / 2010 | £142,180 |
| 15↓ (9) | Winter's Bone / 2010 | £126,865 |
| 16 | Peepli [live] / 2010 | £43,221 |
| 17 | Enter the Void / 2010 | £26,639 |
| 18 | Worlds Greatest Dad / 2010 | £19,093 |
| 19↑ (20) | The Illusionist / 2010 | £14,882 |
| 20 | The Wildest Dream Conquest of Everest / 2010 | £4,694 |
| 21↑ (22) | Soulboy / 2010 | £4,067 |
| 22 | Budrus / 2010 | £3,420 |
| 23 | Frozen / 2010 | £1,859 |
| 24 ⇅ (re) | The Kid / 2000 | £1,677 |
| 25 | True Legend / 2010 | £1,108 |
| 26↓ (24) | F / 2010 | £329 |
| 27 | Confucius / 2010 | £92 |
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