| Rank | Title | Weekend |
|---|---|---|
| 1 | The Other Guys / 2010 | £1,980,601 |
| 2 | Devil / 2010 | £807,292 |
| 3↓ (1) | Resident Evil: Afterlife / 2010 | £727,908 |
| 4↓ (2) | Toy Story 3 / 2010 | £583,013 |
| 5↓ (3) | Grown Ups / 2010 | £513,881 |
| 6↓ (5) | Tamara Drewe / 2010 | £432,337 |
| 7↓ (4) | The Last Exorcism / 2010 | £321,585 |
| 8↑ (13) | Marmaduke / 2010 | £279,392 |
| 9 | Winter's Bone / 2010 | £267,408 |
| 10↑ (15) | Diary of a Wimpy Kid / 2010 | £241,390 |
| 11↓ (6) | Scott Pilgrim Vs. the World / 2010 | £233,228 |
| 12↓ (7) | Going the Distance / 2010 | £220,359 |
| 13↑ (14) | Inception / 2010 | £201,162 |
| 14↓ (11) | Salt / 2010 | £190,011 |
| 15↓ (8) | Cyrus / 2010 | £172,584 |
| 16↓ (10) | The Expendables / 2010 | £160,147 |
| 17 | Just Wright / 2010 | £82,513 |
| 18 | The Kid / 2010 | £22,974 |
| 19 | I'm Still Here / 2010 | £22,730 |
| 20↓ (17) | The Illusionist / 2010 | £22,435 |
| 21 | Ik Kudi Punjab Di / 2010 | £19,683 |
| 22 ⇅ | Soulboy / 2010 | £11,248 |
| 23 | Savage / 2010 | £6,744 |
| 24 | F / 2010 | £6,103 |
| 25 | Night of the Demon's / 2010 | £1,959 |
| 26 | A Distant Mirage / 2010 | £638 |
| 27↓ (20) | Bonded By Blood / 2010 | £356 |
| 28 | The Horde / 2010 | £336 |
| 29↓ (22) | London River / 2010 | £8 |
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