| Rank | Title | Weekend |
|---|---|---|
| 1 | Due Date / 2010 | £2,346,089 |
| 2 | Jackass 3D / 2010 | £1,696,909 |
| 3↓ (2) | Despicable Me / 2010 | £1,177,507 |
| 4↓ (1) | Saw: The Final Chapter / 2010 | £1,068,403 |
| 5↓ (3) | Paranormal Activity 2 / 2010 | £687,747 |
| 6↓ (4) | Red / 2010 | £595,362 |
| 7↓ (5) | The Social Network / 2010 | £541,763 |
| 8 | Let Me In / 2010 | £488,172 |
| 9 | Another Year / 2010 | £355,626 |
| 10↓ (6) | Burke and Hare / 2010 | £333,637 |
| 11 | Golmaal 3 / 2010 | £259,611 |
| 12↓ (9) | The Kids Are All Right / 2010 | £249,110 |
| 13↓ (8) | Alpha and Omega / 2010 | £230,543 |
| 14↓ (7) | Legend of the Guardians: The Owls of Ga'hoole / 2010 | £217,775 |
| 15 | Action Replayy / 2010 | £154,911 |
| 16↓ (15) | Made In Dagenham / 2010 | £36,146 |
| 17↓ (14) | Africa United / 2010 | £30,519 |
| 18↑ (20) | The Illusionist / 2010 | £4,803 |
| 19↓ (16) | Mr. Nice / 2010 | £4,439 |
| 20↑ (23) | Tamara Drewe / 2010 | £2,149 |
| 21↓ (18) | The Arbor / 2010 | £1,921 |
| 22↓ (17) | Jhootha Hi Sahi / 2010 | £702 |
| 23↑ (24) | Soulboy / 2010 | £532 |
| 24↑ (25) | Over Your Cities Grass Will Grow / 2010 | £125 |
| 25 | Red and White / 2010 | £87 |
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