| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Due Date / 2010 | £1,898,324 |
| 2 | Skyline / 2010 | £1,206,207 |
| 3↔ (3) | Despicable Me / 2010 | £1,089,160 |
| 4↓ (2) | Jackass 3D / 2010 | £1,059,714 |
| 5↓ (4) | Saw: The Final Chapter / 2010 | £537,953 |
| 6↔ (6) | Red / 2010 | £509,973 |
| 7↔ (7) | The Social Network / 2010 | £422,895 |
| 8↓ (5) | Paranormal Activity 2 / 2010 | £392,009 |
| 9↑ (13) | Alpha and Omega / 2010 | £298,311 |
| 10↓ (9) | Another Year / 2010 | £297,309 |
| 11↓ (8) | Let Me In / 2010 | £292,988 |
| 12↓ (10) | Burke and Hare / 2010 | £196,229 |
| 13↑ (14) | Legend of the Guardians: The Owls of Ga'hoole / 2010 | £187,684 |
| 14↓ (12) | The Kids Are All Right / 2010 | £161,374 |
| 15 | You Again / 2010 | £145,034 |
| 16 | My Afternoons With Marguerite / 2010 | £43,607 |
| 17↓ (16) | Made In Dagenham / 2010 | £33,788 |
| 18 | We Are What We Are / 2010 | £30,596 |
| 19↓ (17) | Africa United / 2010 | £20,489 |
| 20↓ (18) | The Illusionist / 2010 | £5,673 |
| 21↓ (19) | Mr. Nice / 2010 | £2,747 |
| 22↓ (21) | The Arbor / 2010 | £1,543 |
| 23↑ (24) | Over Your Cities Grass Will Grow / 2010 | £1,158 |
| 24↓ (23) | Soulboy / 2010 | £532 |
| 25↓ (20) | Tamara Drewe / 2010 | £224 |
| 26 | Aftershock / 2010 | £187 |
| 27 | Brilliantlove / 2010 | £63 |
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