| Rank | Title | Weekend |
|---|---|---|
| 1 | Saw: The Final Chapter / 2010 | £3,600,083 |
| 2↔ (2) | Despicable Me / 2010 | £2,581,073 |
| 3↓ (1) | Paranormal Activity 2 / 2010 | £1,845,337 |
| 4↓ (3) | Red / 2010 | £1,184,344 |
| 5↓ (4) | The Social Network / 2010 | £1,070,411 |
| 6 | Burke and Hare / 2010 | £942,894 |
| 7↓ (5) | Legend of the Guardians: The Owls of Ga'hoole / 2010 | £502,951 |
| 8↓ (6) | Alpha and Omega / 2010 | £458,812 |
| 9 | The Kids Are All Right / 2010 | £411,960 |
| 10↓ (7) | Vampires Suck / 2010 | £313,911 |
| 11↓ (8) | Easy A / 2010 | £149,044 |
| 12↓ (10) | Wall Street: Money Never Sleeps / 2010 | £124,832 |
| 13↓ (9) | Life As We Know It / 2010 | £124,360 |
| 14↓ (11) | Africa United / 2010 | £105,151 |
| 15↓ (12) | Made In Dagenham / 2010 | £94,110 |
| 16↔ (16) | Mr. Nice / 2010 | £26,331 |
| 17↔ (17) | Jhootha Hi Sahi / 2010 | £15,823 |
| 18↔ (18) | The Arbor / 2010 | £7,532 |
| 19 | The Hunter / 2010 | £5,777 |
| 20↑ (21) | The Illusionist / 2010 | £3,755 |
| 21 | Involuntary / 2010 | £2,426 |
| 22 | Spiderhole / 2010 | £1,422 |
| 23↓ (22) | Tamara Drewe / 2010 | £294 |
| 24↓ (23) | Soulboy / 2010 | £292 |
| 25↓ (24) | Over Your Cities Grass Will Grow / 2010 | £108 |
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