| Rank | Title | Weekend |
|---|---|---|
| 1 | Fantastic Beasts and Where to Find Them / 2016 | £15,333,146 |
| 2↓ (1) | Arrival / 2016 | £1,496,205 |
| 3↔ (3) | Trolls / 2016 | £1,241,574 |
| 4 | André Rieu: Christmas In London / 2016 | £1,180,208 |
| 5↓ (2) | Doctor Strange / 2016 | £941,628 |
| 6↓ (4) | The Accountant / 2016 | £470,079 |
| 7↓ (5) | A Street Cat Named Bob / 2016 | £370,334 |
| 8↓ (6) | Nocturnal Animals / 2016 | £248,330 |
| 9↓ (7) | The Girl On the Train / 2016 | £186,805 |
| 10↓ (8) | Storks / 2016 | £175,637 |
| 11↓ (9) | Jack Reacher Never Go Back / 2016 | £94,358 |
| 12↑ (13) | I, Daniel Blake / 2016 | £69,527 |
| 13↓ (11) | Bridget Jones's Baby / 2016 | £68,612 |
| 14↓ (10) | The Light Between Ocean's / 2016 | £61,224 |
| 15↓ (14) | Chaar Sahibzaade 2 Rise of Banda Singh Bahadur / 2016 | £57,013 |
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