| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Fantastic Beasts and Where to Find Them / 2016 | £8,892,489 |
| 2 | Allied / 2016 | £1,331,919 |
| 3↔ (3) | Trolls / 2016 | £834,362 |
| 4 | Bad Santa 2 / 2016 | £799,156 |
| 5↓ (2) | Arrival / 2016 | £778,449 |
| 6 | A United Kingdom / 2016 | £618,652 |
| 7↓ (5) | Doctor Strange / 2016 | £454,088 |
| 8↓ (4) | André Rieu: Christmas In London / 2016 | £303,519 |
| 9 | Dear Zindagi / 2016 | £171,496 |
| 10 | Paterson / 2016 | £169,911 |
| 11↓ (6) | The Accountant / 2016 | £160,412 |
| 12↓ (7) | A Street Cat Named Bob / 2016 | £132,373 |
| 13↓ (10) | Storks / 2016 | £121,318 |
| 14↓ (8) | Nocturnal Animals / 2016 | £91,433 |
| 15↑ (21) | Your Name. / 2016 | £66,339 |
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