| Directed by | ||
|---|---|---|
 | Peter Hyams | |
| Starring | ||
|---|---|---|
 | Roy Scheider | Dr. Heywood Floyd |
 | John Lithgow | Dr. Walter Curnow |
 | Helen Mirren | Tanya Kirbuk |
| Bob Balaban | Dr. R. Chandra |
| Keir Dullea | Dave Bowman |
| Douglas Rain | HAL 9000 |
| Madolyn Smith Osborne | Caroline Floyd |
| Dana Elcar | Dimitri Moisevitch |
| Taliesin Jaffe | Christopher Floyd |
| James McEachin | Victor Milson |
| Mary Jo Deschanel | Betty Fernandez, Bowman's Wife |
| Elya Baskin | Maxim Brajlovsky |
| Saveliy Kramarov | Dr. Vladimir Rudenko |
| Oleg Rudnik | Dr. Vasili Orlov |
| Natasha Shneider | Irina Yakunina |
| Vladimir Skomarovsky | Yuri Svetlanov |
| Victor Steinbach | Mikolaj Ternovsky |
| Jan Triska | Alexander Kovalev |
| Larry Carroll | Anchorman on TV |
| Herta Ware | Jessie Bowman |
| Cheryl Carter | Nurse |
| Ron Recasner | Hospital Neurosurgeon |
| Robert Lesser | Dr. Hirsch |
| Candice Bergen | SAL 9000 |
| Delana Michaels | Commercial Announcer |
| Gene McGarr | Commercial Announcer |
| Arthur C. Clarke | Man on Park Bench |
| Gary Lockwood | Dr. Frank Poole |
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