| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Sex and the City 2 / 2010 | £1,489,833 |
| 2 | Letters to Juliet / 2010 | £793,425 |
| 3↓ (2) | StreetDance 3D / 2010 | £715,317 |
| 4↓ (3) | Prince of Persia: The Sands of Time / 2010 | £507,855 |
| 5 | Brooklyn's Finest / 2010 | £468,279 |
| 6↓ (4) | Death At a Funeral / 2010 | £414,711 |
| 7↓ (6) | Tooth Fairy / 2010 | £367,396 |
| 8↓ (5) | Robin Hood / 2010 | £362,397 |
| 9↓ (8) | She's Out of My League / 2010 | £175,920 |
| 10↓ (7) | 4.3.2.1 / 2010 | £132,048 |
| 11↓ (10) | Space Chimps 2: Zartog Strikes Back / 2010 | £122,537 |
| 12 | Greenberg / 2010 | £118,804 |
| 13↓ (9) | Iron Man 2 / 2010 | £113,566 |
| 14↓ (11) | Raajneeti / 2010 | £84,230 |
| 15↓ (12) | The Killer Inside Me / 2010 | £66,143 |
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