| Rank | Title | Weekend |
|---|---|---|
| 1↔ (1) | Sex and the City 2 / 2010 | £2,473,043 |
| 2↔ (2) | StreetDance 3D / 2010 | £1,144,239 |
| 3↔ (3) | Prince of Persia: The Sands of Time / 2010 | £821,661 |
| 4 | Death At a Funeral / 2010 | £696,280 |
| 5↓ (4) | Robin Hood / 2010 | £647,195 |
| 6↓ (5) | Tooth Fairy / 2010 | £538,366 |
| 7 | 4.3.2.1 / 2010 | £433,218 |
| 8 | She's Out of My League / 2010 | £400,554 |
| 9↓ (6) | Iron Man 2 / 2010 | £226,314 |
| 10↓ (7) | Space Chimps 2: Zartog Strikes Back / 2010 | £220,989 |
| 11 | Raajneeti / 2010 | £218,783 |
| 12 | The Killer Inside Me / 2010 | £124,006 |
| 13↓ (8) | The Losers / 2010 | £110,255 |
| 14↓ (11) | Furry Vengeance / 2010 | £91,042 |
| 15↓ (10) | Four Lions / 2010 | £83,609 |
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