| Rank | Title | Weekend |
|---|---|---|
| 1 | The Twilight Saga: Eclipse / 2010 | £13,756,653 |
| 2↓ (1) | Shrek Forever After / 2010 | £4,591,105 |
| 3 | Predators / 2010 | £2,203,193 |
| 4↓ (2) | Get Him to the Greek / 2010 | £610,705 |
| 5↓ (3) | Killers / 2010 | £157,615 |
| 6↓ (4) | Sex and the City 2 / 2010 | £107,884 |
| 7↓ (6) | Heartbreaker / 2010 | £84,417 |
| 8↓ (5) | I Hate Luv Storys / 2010 | £78,353 |
| 9↓ (7) | Prince of Persia: The Sands of Time / 2010 | £48,268 |
| 10 | Milenge Milenge / 2010 | £48,172 |
| 11↑ (12) | Tooth Fairy / 2010 | £46,482 |
| 12 | Leaving / 2010 | £35,532 |
| 13↓ (8) | Death At a Funeral / 2010 | £31,298 |
| 14↑ (16) | White Material / 2010 | £23,285 |
| 15↓ (11) | Robin Hood / 2010 | £22,135 |
| 16↓ (13) | StreetDance 3D / 2010 | £20,948 |
| 17↑ (19) | Nanny Mcphee and the Big Bang / 2010 | £14,578 |
| 18↓ (17) | Four Lions / 2010 | £14,471 |
| 19 | London River / 2010 | £12,690 |
| 20 ⇅ (re) | Wild Target / 2010 | £6,239 |
| 21↓ (20) | The Killer Inside Me / 2010 | £4,082 |
| 22 | Madrasapattinam / 2010 | £3,977 |
| 23↑ (24) | The Ghost / 2010 | £2,652 |
| 24↓ (21) | 4.3.2.1 / 2010 | £1,675 |
| 25 | Gangster's Paradise: Jerusalema / 2010 | £822 |
| 26↓ (23) | Black Death / 2010 | £708 |
| 27 | Frownland / 2010 | £143 |
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