| Rank | Title | Weekend |
|---|---|---|
| 1 | Inception / 2010 | £5,912,814 |
| 2↔ (2) | Shrek Forever After / 2010 | £4,198,874 |
| 3↓ (1) | The Twilight Saga: Eclipse / 2010 | £3,390,512 |
| 4↓ (3) | Predators / 2010 | £893,439 |
| 5↓ (4) | Get Him to the Greek / 2010 | £440,282 |
| 6↓ (5) | Killers / 2010 | £71,486 |
| 7↔ (7) | Heartbreaker / 2010 | £68,757 |
| 8↓ (6) | Sex and the City 2 / 2010 | £51,777 |
| 9↑ (12) | Leaving / 2010 | £50,241 |
| 10 | The Concert / 2010 | £38,053 |
| 11↓ (8) | I Hate Luv Storys / 2010 | £36,679 |
| 12 | Mel Karade Rabba / 2010 | £33,995 |
| 13↓ (11) | Tooth Fairy / 2010 | £30,235 |
| 14↓ (10) | Milenge Milenge / 2010 | £22,334 |
| 15↓ (9) | Prince of Persia: The Sands of Time / 2010 | £21,232 |
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