| Rank | Title | Weekend |
|---|---|---|
| 1 | Toy Story 3 / 2010 | £21,187,264 |
| 2↓ (1) | Inception / 2010 | £4,172,568 |
| 3↔ (3) | The Twilight Saga: Eclipse / 2010 | £1,436,792 |
| 4↓ (2) | Shrek Forever After / 2010 | £1,223,759 |
| 5 | The Rebound / 2010 | £360,015 |
| 6↓ (4) | Predators / 2010 | £305,424 |
| 7 | Khatta Meetha / 2010 | £124,104 |
| 8↓ (5) | Get Him to the Greek / 2010 | £119,424 |
| 9 | Splice / 2010 | £110,225 |
| 10↓ (9) | Leaving / 2010 | £39,409 |
| 11↓ (7) | Heartbreaker / 2010 | £35,431 |
| 12↓ (10) | The Concert / 2010 | £26,268 |
| 13↓ (12) | Mel Karade Rabba / 2010 | £19,892 |
| 14 ⇅ (re) | How to Train Your Dragon / 2010 | £17,935 |
| 15↓ (8) | Sex and the City 2 / 2010 | £15,516 |
| 16 | Thillalangadi / 2010 | £13,685 |
| 17↑ (27) | Nanny Mcphee and the Big Bang / 2010 | £11,509 |
| 18 | Baarìa / 2009 | £7,385 |
| 19 | City Island / 2009 | £6,936 |
| 20↔ (20) | London River / 2010 | £5,093 |
| 21↓ (19) | Four Lions / 2010 | £4,902 |
| 22↓ (17) | StreetDance 3D / 2010 | £4,293 |
| 23↓ (18) | Robin Hood / 2010 | £2,750 |
| 24 | Ivul / 2010 | £2,327 |
| 25↔ (25) | Went the Day Well? / 1942 Re-Release | £1,281 |
| 26↔ (26) | The Ghost / 2010 | £878 |
| 27↓ (22) | Wild Target / 2010 | £672 |
| 28↑ (29) | 4.3.2.1 / 2010 | £104 |
| 29↓ (24) | The Killer Inside Me / 2010 | £20 |
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