| Rank | Title | Weekend |
|---|---|---|
| 1 | Paranormal Activity 2 / 2010 | £3,764,722 |
| 2↓ (1) | Despicable Me / 2010 | £2,589,170 |
| 3 | Red / 2010 | £1,662,472 |
| 4↓ (2) | The Social Network / 2010 | £1,538,571 |
| 5 | Legend of the Guardians: The Owls of Ga'hoole / 2010 | £737,444 |
| 6 | Alpha and Omega / 2010 | £643,425 |
| 7↓ (3) | Vampires Suck / 2010 | £530,136 |
| 8 | Easy A / 2010 | £277,975 |
| 9↓ (5) | Life As We Know It / 2010 | £263,134 |
| 10↓ (4) | Wall Street: Money Never Sleeps / 2010 | £258,968 |
| 11 | Africa United / 2010 | £177,827 |
| 12↓ (7) | Made In Dagenham / 2010 | £156,712 |
| 13↓ (6) | The Town / 2010 | £126,777 |
| 14 | Ramona and Beezus / 2010 | £84,475 |
| 15↓ (8) | The Other Guys / 2010 | £75,250 |
| 16↓ (11) | Mr. Nice / 2010 | £38,048 |
| 17 | Jhootha Hi Sahi / 2010 | £32,685 |
| 18 | The Arbor / 2010 | £16,883 |
| 19 | Mary and Max / 2010 | £12,052 |
| 20 | Hisss / 2010 | £8,519 |
| 21↓ (20) | The Illusionist / 2010 | £5,662 |
| 22↓ (18) | Tamara Drewe / 2010 | £5,039 |
| 23↓ (22) | Soulboy / 2010 | £1,690 |
| 24↓ (21) | Over Your Cities Grass Will Grow / 2010 | £646 |
| 25 | Cehennem 3D / 2010 | £597 |
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